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Laurie Metcalf played Roseanne's sister Jackie on 'Roseanne.' She also appeared in the 1989 comedy film 'Uncle Buck' and later went on to appear on shows such as '3rd Rock From The Sun,' 'Malcolm in the Middle,' 'Frasier,' 'Monk,' 'Grey's Anatomy' and played Carolyn Bigsby on ABC's 'Desperate Housewives.' She had parts in movies such as 'Scream 2' in 1997 and 'Stop-Loss' in 2008 and voiced Andy's Mom in all three of Disney-Pixar's 'Toy Story' films.
Metcalf reunited with her 'Roseanne' co-stars Johnny Galecki and Sara Gilbert on 'The Big Bang Theory,' playing Mary Cooper in a recurring role. Her most recent appearance was in 2010.
Metcalf married Jeff Perry in 1983. They had a daughter named Zoe, who was born in 1984. Metcalf and Perry divorced in 1992. In 1993, the actress married Matt Roth. They have three children - Will, Donovan and a daughter named Mae, who was born in 2005 via a surrogate mother. Roth filed for divorce on Sept. 12, 2011.
(Pictured: Laurie Metcalf appears in scenes from 'Roseanne,' 'The Big Bang Theory' and 'Uncle Buck.')
( Photo / Wind Dancer Productions / Carsey-Werner Company / Paramount Television / ABC / CBS / Universal Pictures)